Leg ulcers, venous Ulcers
Study 1
Leg ulcers, venous Ulcers**, wound healing disorder
Authors, title of the study and source:
Stiller MJ, Pak GH, Shupack JL, Thaler S, Kenny C, Jondreau L: A portable pulsed electromagnetic field (PEMF) device to enhance healing of recalcitrant venous ulcers: a double – blind, placebo-controlled clinical trial. Br J Dermatol 1992;127:147-154
Number of patients: 31
Disease:
Leg ulcers due to venous stasis, which were not curable with standard therapy over > 4 weeks, and showed no tendency to heal itself. Patients with arterial disorders and thrombosis were excluded.
Treatment:
3 pcs./ day, bidirectional symmetrical 22 G. 8 weeks
Improvement:
In the MFT group the wound area had decreased by 47:7 %; but in the placebo group showed and increase of 42,3 %. In the MFT group 50 % of the patients were cured or remarkably better, while 0 % were cured in the placebo group and 54 % were worse.
The MFT group showed a significant decrease in the wound depth and pain loss. No side effects.
Remarks:
Multicentre study (8 centre in USA); funded by the National Institute of Health.
Stimulation with sine waves induces the differentiation of human connective tissue cells in the skin (fibroblasts) and increases collagen formation and protein synthesis (Lit) Furthermore, there is a new vessel formation (angiogenesis), endothelial cells grow faster (endothelium), and parts of the DNS are increasingly being written off ( mRNA transcript), the hormonal regulation is affected, enzyme activity increases, the cell receptor expression increases. (Literature quotation of Science)
Study 2
Leg ulcers, venous Ulcers**, wound healing disorder
Authors, title of the study and source:
Leran M, Zaffuto S, Bagnacani M, Annovi M, Moratti A, Cadessi R. Effect of low frequency pulsing electromagnetic field on skin ulcers of venous origin in humans: a double-blind study. J. Orthop. Res. 1990, 276-282
Number of patients: 44
Disease:
Venous ulcers caused by venous insufficiency, post-thrombotic phlebitis, not arterial, no steroids, no systemic diseases
Treatment:
3-4 St/Tg, > 90 Tage, Sägezahn, 28 G, 75 Hz.
Improvement:
In MFT group 66.6 % were healed, in the placebo group 31 %.
Patients were observed up to 1 year. Then in the MFT group were 88.8% healed in the control group 66%.
Not a single patient of the MFT group deteriorated during the treatment. In the MFT group at the follow up check during the first year 25% of Ulcers came back, in the placebo group 50%
Remarks:
Conclusion: The MFT has a wound healing and preventative against new ulcers effect during and after the therapy.
** The treatment with pulsating magnetic field seems to be superior because of double blind controlled randomized studies of the Placebo-treatment.
* The treatment with pulsating magnetic field seems to be superior because of the controlled studies of the control-treatment.
